Long-Term Safety and Efficacy of Clomiphene Citrate for the Treatment of Hypogonadism

Studies show that when men produce enough testosterone to meet the correct levels for their reproductive health, the higher their sperm count is to increase the chances of having a successful pregnancy. For example, using Clomid should reflect a 100% growth of current testosterone levels. This means that if a man has a T (testosterone) count of around 250, using the medication should result in a T count of 500—a significant increase to help with getting pregnant. You may already be familiar withclomiphene citrate (Clomid), a popular brand-name prescription medication typically used for ovarian stimulation or ovulation induction.

• Therefore, close monitoring by a healthcare provider is crucial to ensure the safe and effective use of this medication.
• Depending on your response, this dosage may be adjusted up to 50 mg per day when needed.
• Making healthy changes to these factors can drastically improve fertility, so it’s best to examine what areas you can improve on or consult a physician to pinpoint your problems.
• The success rates of Clomid treatment can also be influenced by various factors.
• “If these two areas don’t improve on enclomiphene to the patient’s satisfaction, I often add low dose TRT to [resolve] these symptoms,” Jandes says.

What Is Clomid?

For example, some men might need surgery to correct a physical cause of infertility (such as a varicocele, an enlargement of the veins within the scrotum). In other cases, medications like antibiotics may help treat infections that impair fertility. For men who choose to take another route to treat infertility or increase their testosterone, there are alternatives to clomiphene citrate. “Because It works by tricking your body into making more of its own testosterone (and thus increasing sperm count), stopping it will just take you back to normal levels of production,” says Calvert. Rarely, sperm counts can paradoxically decrease with clomiphene citrate , which can be reversed by changing to another type of estrogen blocker, such as tamoxifen. Hone delivers treatments for low T—including clomiphene citrate—to your doorstep, if prescribed.

When and How to Take Clomid

Consulting with a knowledgeable healthcare professional who specializes in hormone therapy is essential to ensure that the dosage is tailored to meet your specific needs and optimize treatment outcomes. When considering Clomid therapy, it is crucial to work closely with a healthcare provider to determine the appropriate dosage and monitoring schedule. Regular blood tests are typically conducted to assess testosterone levels and adjust the dosage as needed to achieve optimal results while minimizing potential side effects. [6] In fact, the treatment group experienced a 36.7% pregnancy rate, nearly three times that of the control group (13%). But because the men were taking both clomiphene citrate and vitamin E, it’s impossible to understand the efficacy of either drug alone from this study.

Dosage and Treatment

If ovulation occurs but you do not get pregnant after 3 treatment cycles, your doctor may stop treatment and evaluate your infertility further. Dr. John Whitfield is a board-certified gynecologist and the owner of private practice Signature GYN Services in Fort Worth, Texas. He has more than three decades of medical experience and has delivered over 2,000 babies to families in the Fort Worth area. He now focuses his practice exclusively on gynecology and gynecologic surgery, staying current with the latest medical research and developments.

Some of the studies reviewed demonstrated a moderate improvement in sperm count in males with low sperm count or unexplained infertility. Causes of male fertility tend to fall into two categories, according to Griffith – it’s either a problem with sperm production or obstruction of the reproductive tract. Diagnoses are determined through bloodwork, imaging or exploratory medical procedures. Insulin costs Clomid is sometimes prescribed to men as well because it may increase sperm count, but this article focuses on how Clomid affects female reproductive organs. Sixteen patients (10%) were classified before treatment as hypergonadotropic hypogonadism. In this hypergonadotropic hypogonadism group 6/16 were biochemical responders (38%), of which the patient with Klinefelter.

Since clomid works as a stimulant for sperm production, one of the main benefits of its use is to improve sperm count and increase testosterone levels. Human chorionic gonadotropin (hCG) is a hormonal treatment that can also be used to increase testosterone levels in men who suffer from symptoms of low testosterone or hypogonadism (testosterone deficiency). This drug is typically a last resort treatment because it requires two to three injections per week, which most patients would rather avoid. Researchers need to carry out more studies to determine whether clomiphene citrate is effective for treating male infertility, which types of male infertility it might treat, and what the ideal dosage may be.

“This can be a shocking change for some guys to go back to the symptoms that they used to have. Before starting this drug, I tell my patients that they should anticipate transitioning to TRT after they are done having kids,” adds Calvert. In some cases, your doctor will prescribe Clomid for reasons other than infertility.